Award details

(A) LC-MS/MS to investigate the metabolism of bioactive compounds in vivo and in vitro

Reference	JE514264
Principal Investigator / Supervisor	Dr C Rice-Evans
Co-Investigators / Co-Supervisors	Dr Sukhvinder Bansal, Professor Marc Brown, Professor David Cowan, Professor Robert Hider, Dr Andrew Kicman
Institution	King's College London
Department	Division of Biochemistry & Molecular Bio
Funding type	Research
Value (£)	90,376
Status	Completed
Type	Research Grant
Start date	27/03/2001
End date	27/03/2006
Duration	60 months

Abstract

The equipment requested is to support collaborative, multidisciplinary research projects between the Wolfson Centre for Age-Related Diseases in the School of Biomedical Sciences, and the Department of Pharmacy in the School of Life and Health Sciences, of Kings College, London. The common theme is the enhancement of research into bioactive compounds as potential health beneficial or therapeutic agents, their metabolism and mechanisms of action. The research programme will apply the sensitive and discriminating analytical tools provided by LC-MS/MS to the further analysis and structural characterisation of the metabolites of four major classes of bioactive compounds with distinct functions. These are: flavonoids as dietary antioxidants, novel peptide drugs and iron chelators with potentially therapeutic applications, and steroids. LC-MS/MS provides high sensitivity (ppb in complex matrices) detailed structural characterisation of such metabolites in small sample volumes and not only determines molecular weights but also further structural detail through controlled fragmentation of the compounds. Once these metabolites are identified, quantitative information on the rates of absorption, metabolism and degradation will be obtained and the implications of their mechanisms of metabolism for their functional properties will be assessed.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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