Award details

(A) Characterisation of the physical structure and biointeractions of therapeutic systems using confocal laser scanning microscopy

Reference	JE412702
Principal Investigator / Supervisor	Professor Duncan Craig
Co-Investigators / Co-Supervisors	Professor SEAN Gorman, Professor David Jones, Professor Peter Taylor, Professor Michael Wilson, Professor David Woolfson
Institution	Queen's University of Belfast
Department	Sch of Pharmacy
Funding type	Research
Value (£)	87,913
Status	Completed
Type	Research Grant
Start date	28/03/2000
End date	28/09/2000
Duration	6 months

Abstract

The project involves the development of CLSM as a means of studying the interaction of drug delivery systems with biological tissues. In particular, the approach involves the investigation of the delivery systems themselves, the nature of the biological target tissue and the nature of the interaction when the delivery system is in contact with the target site. The consortium involved comprises three academic (The School of Pharmacy, The Queen's University of Belfast; The Eastman Dental Institute, University of London; The School of Pharmacy, University of London) and three industrial institutions (Galen Pharmaceuticals, Reckitt and Colman, Leica Microsystems (UK) Ltd.) with complementary skill bases and research interests. The specific areas of interest include bioadhesion of polysaccharide delivery systems to oesophageal tissue, the characterisation of intravaginal ring systems for sustained delivery of hormonal drugs, the transport of drugs across cervical tissue, the penetration and kill of microbial biofilms by fluoroquinolones, the study of the architecture of oral biofilms and the site-selective delivery of zinc (II) phthalocyanine (ZnPc) to peroxidation-sensitive targets within carcinomas and melanomas. Over and above the information obtained on these particular issues, it is intended that the confocal facility will provide a focus for future collaborations between members of the consortium.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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