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(A) Conventional and stopped-flow fluorescence for studies of protein structure and function
Reference
JE412690
Principal Investigator / Supervisor
Professor Anthony Lee
Co-Investigators /
Co-Supervisors
Professor Michael Gore
,
Dr D Wilton
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
49,636
Status
Completed
Type
Research Grant
Start date
18/04/2000
End date
18/10/2000
Duration
6 months
Abstract
Conventional and stopped-flow fluorescence are being used to study a variety of problems in protein structure and function including: fluorescence energy transfer studies of the structure of Ca-ATPase and phospholamban; fluorescence quenching studies of simple alpha-helical peptides in lipid bilayers; structural studies of porins in lipid bilayers; structural studies of C2 domains of protein kinases and binding of sPLA2 to bilayers; rapid kinetic studies of binding of C2 domains and sPLA2 to lipid bilayers; rapid kinetic studies of the mechanism of diacylglycerol kinase; the binding of metal ions to inositol monophosphatase from mammalian brain; binding of fatty acids to fatty acid binding protein; the interaction between novel bacterial immunoglobulin-binding domains and immunoglobulins; the action of chaperonins; folding/unfolding pathways of proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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