Award details

(A) Fermentation and downstream processing facility for the Krebs Institute at the University of Sheffield

Reference	JE412666
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors	Professor David Rice
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	40,304
Status	Completed
Type	Research Grant
Start date	09/05/2000
End date	09/11/2000
Duration	6 months

Abstract

The study of molecular microbiology is one of the key research themes of the Krebs Institute at the University of Sheffield. Within this broad grouping specific programmes investigate: bacterial genetics and oxygen metabolism; nitric oxide metabolism; bacterial metal ion resistance; microbial pathogenicity; and the molecular mechanisms of gene regulation. These activities are all integrated into the overall research philosophy of the Institute. For example structure determination using 2D and 3D crystallography are being applied to bacterial oxidases, membrane transporters, novel toxins, and microbial drug targets. Bacteria are also used as factories to produce specific overexpressed proteins for biochemical and structural analyses. However, all of these programmes are being hindered to some extent by the lack of modern fermentation and downstream processing equipment that will allow growth of microbes under defined conditions and efficient disruption of the biomass generated. This proposal will establish such a facility within the Krebs Institute.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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