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(A) Towards an understanding of gene function in antibiotic-producing Streptomyces
Reference
JE412639
Principal Investigator / Supervisor
Professor Paul Dyson
Co-Investigators /
Co-Supervisors
Institution
Swansea University
Department
Biological Sciences
Funding type
Research
Value (£)
55,436
Status
Completed
Type
Research Grant
Start date
31/05/2000
End date
30/11/2000
Duration
6 months
Abstract
Investment is urgently needed for equipment to support the following investigations into gene function in antibiotic-producing Streptomyces: 1). systematic transposon mutagenesis of the model species, Streptomyces coelicolor, relating phenotype to genotype in each mutant; 2). molecular characterisation of the milbemycin polyketide synthase gene cluster; 3). molecular genetic characterisation of the control of gene expression in response to changes in osmolarity; 4). elucidation of the control of gene expression in Streptomyces by plant signalling compounds; 5). analysis of a novel type of site-specific DNA modification; and 6). investigations into the genetics of oxidative stress and cell ageing in antibiotic-producing mycelia. The areas of research also provide an excellent training ground for postgraduate students.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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