Award details

(A) Proteomic responses to environmental nutritional and genetic factors in prokaryotes and eukaryotes

Reference	JE412631
Principal Investigator / Supervisor	Dr Nicholas Walton
Co-Investigators / Co-Supervisors	Dr Michael Naldrett
Institution	Quadram Institute Bioscience
Department	Food Safety Science Division
Funding type	Research
Value (£)	127,876
Status	Completed
Type	Research Grant
Start date	30/06/2000
End date	30/12/2000
Duration	6 months

Abstract

This proposal is for equipment to establish a Joint Proteomics Facility for IFR and JIC, complementing a MALDI-TOF mass spectrometer which is shortly to be commissioned (June 1999). The principal aims of the research are to apply proteomic analysis to two general categories of investigation: 1) studies involving comparisons of patterns of expressed proteins associated with defined physiological, developmental, genetic or taxonomic states; and the use of these data in gene identification and/or discovery; and 2) studies focusing on the elucidation of specific molecular interactions, for example of individual proteins involved in developmental processes or hormonal responses. Within these categories, a diversity of problems will be tackled. Conspicuous amongst these are developmental and environmental responses in Streptomyces (JIC Streptomyces Group), adaptive responses of food-borne bacterial pathogens (newly-formed Division of Food Safety Science, IFR) and studies of nutrient-gene interactions (IFR). Investigations involving the study of specific protein-protein interactions include the gibberellin signal-transduction pathway, transcription- factor control of flowering in Arabidopsis and cell-cycle regulation in Aspergillus (JIC).

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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