Award details

(A) Molecular interactions: the starting point of cellular regulation

Reference	JE412629
Principal Investigator / Supervisor	Professor David Fernig
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	63,000
Status	Completed
Type	Research Grant
Start date	22/03/2000
End date	22/09/2000
Duration	6 months

Abstract

The dynamic regulation of cellular function is achieved by changes in the interactions between proteins, nucleic acids, polysaccharides and lipids. Optical biosensors allow the determination of the kinetic characteristics of molecular interactions. We have successfully used a manual optical biosensor to analyse protein-polysaccharide interactions. The programme of research comprises: the foot-printing of binding sites and the verification of the structural determinants of the interactions, the determination of stoichiometry, the analysis of the effects of receptor dimerisation, the identification of partners of orphan proteins and the development of novel methodologies. To develop and apply the novel methods requires an automated resonant mirror biosensor; automation has the further advantage that throughput will be much higher, thus facilitating the wider use of the technology within the University.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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