Award details

(A) Pathogenesis studies of the transmissible spongiform encephalopathies

Reference	JE412585
Principal Investigator / Supervisor	Dr Moira Bruce
Co-Investigators / Co-Supervisors	Mrs Karen Brown, Dr Janet Fraser
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	71,388
Status	Completed
Type	Research Grant
Start date	27/06/2000
End date	27/12/2000
Duration	6 months

Abstract

A flow cytometry analyser and confocal laser scanning microscope are required to support a programme of work investigating the pathogenesis and pathology of transmissible spongiform encephalopathies (TSEs) in experimental models. The objectives of this programme are to identify the cells and mechanisms involved in: (1) The spread of infection from the site of entry (e.g. skin, gut) to sites of replication in lymphoid tissues; (2) Replication of infectivity within lymphoid tissues; (3) Spread of infection to and within the CNS; and (4) Neurodegeneration and loss of CNS function. The programme includes studies of the effects of manipulations of the immune system on pathogenesis in lymphoid tissues, as well as detailed morphological analyses of pathological changes in both lymphoid and nervous systems. An understanding of the pathogenesis of TSEs is necessary for the design of therapeutic or prophylactic strategies and will also aid risk assessment in relation to accidental exposure to potentially contaminated tissues.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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