Award details

(A) Confocal time-resolved fluorescence studies of biological systems

Reference	JE412569
Principal Investigator / Supervisor	Professor David Clarke
Co-Investigators / Co-Supervisors	Dr David Berk, Professor Caroline Dive, Professor Kenneth Thomas Douglas, Professor M Ferguson
Institution	The University of Manchester
Department	Manchester Pharmacy School
Funding type	Research
Value (£)	70,828
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	01/03/2001
Duration	6 months

Abstract

This equipment request will provide support for a number of collaborative research proposals including: 1). the development of novel bioresponsive fluorescent probe assemblies to report microscopically in biological materials, particularly for screening, trace bioanalysis and to monitor bioresponsive drug delivery and to track quantitatively and image the delivery of gene and protein therapeutics to tissue/cells; 2). the development of novel target-assembled fluor (e.g. DNA) probes to provide more biospecific detection; and 3). to use confocal laser scanning fluorescence microscopy at the physiological, cellular and molecular levels to study and exploit apoptosis and wound healing (MF) processes. The collaborators recognise that while confocal fluorescence methods have contributed strongly to major biological advances and pharmaceutical technology, further advances are limited by the ability to resolve fluorescently-probed events above and within biological and non-specific background, particularly the low number of events and fluors that need to be resolved microscopically. The equipment applied for will support current grants and contracts in excess of irectorate12M concerning novel fluor probe, biodetection, screening and imaging developments, and will open up new avenues in leading cancer, wound healing, gene and drug delivery research.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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