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(A) Liquid chromatography mass spectrometer/mass spectrometer (LC-MS/MS) instrumentation: application to pharmacokinetics, drug metabolism and drug delivery

Reference	JE412519
Principal Investigator / Supervisor	Professor Brian Houston
Co-Investigators / Co-Supervisors	Dr David Berk, Dr Alan McGown, Professor Malcolm Rowland, Professor Ian Stratford, Dr Geoffrey Warhurst
Institution	The University of Manchester
Department	Manchester Pharmacy School
Funding type	Research
Value (£)	143,384
Status	Completed
Type	Research Grant
Start date	09/05/2000
End date	09/11/2000
Duration	6 months

Abstract

A series of pharmacokinetic/drug delivery projects, all requiring LC-MS/MS capability with high throughput technology, will be undertaken. Specifically, these are: 1). prediction of hepatic drug metabolism in vivo from in vitro data on drugs and their metabolites; 2). prediction of pharmacokinetic properties from physiochemical and structural information; 3). regional distribution and functional relevance of efflux transporters and cytochrome P450 3A4 as modulators of intestinal drug absorption; 4). pharmacokinetic studies on the delivery of therapeutic genes and proteins; 5). development of a bioreductive drug technology platform for the treatment of ischaemic diseases; and 6). pharmacokinetic and metabolic studies with novel anti-tumour compounds.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 1999 (JE4) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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