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Modulation of rectifying electrical synapses
Reference
INS02823
Principal Investigator / Supervisor
Dr William Heitler
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
169,928
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
1. Investigate the pharmacology and mechanisms of chemical modulation of transmission at a rectifying electrical synapse, including modulation by changes in post-synaptic membrane properties, and possible direct changes in junctional conductance. 2. Investigate the cause of a standing difference in resting potential between the pre- and post-synaptic neurones, which biases the rectifying synapse into the low conductance state in the resting condition. 3. Develop a method of short-term culture of the cell bodies of the pre- and post- synaptic neurones, and attempt to establish rectifying and non-rectifying electrical synapses in vivo.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Invertebrate Neurosciences Initiative (INS) [1993-1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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