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Inositide signalling in Chlamydomonas

Reference	ICS00765
Principal Investigator / Supervisor	Professor Robin Irvine
Co-Investigators / Co-Supervisors	Dr N Divecha
Institution	Babraham Institute
Department	Developmental Genetics and Imprinting
Funding type	Research
Value (£)	20,489
Status	Completed
Type	Research Grant
Start date	01/04/1994
End date	01/04/1997
Duration	36 months

Abstract

Chlamydomonas is an organism that split from animals and higher plants at around the same time as they split from each other. It is haploid, easily grown, has a well-defined genetic and autotrophic background, exhibits clear phosphoinositidase C responses, and has an inositol phosphate metabolism very similar to animals. C-eugametos has 3-phosphorylated inositol lipids, and we propose to investigate the production of 3-phosphorylase inositol lipids, and whether and how it is controlled. We also hope to investigate the role of InsP4 in this organism by cloning and sequencing (leading to genetic manipulation) of InsP3 kinase, and studying InsP4 receptors. Finally, we intend to investigate possible activation of phospolipase D coincident with PIC activation, and the existence, and possible stimulation, of a nuclear inositide cycle.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Intracellular Signalling (ICS) [1986]
Funding Scheme	X – not Funded via a specific Funding Scheme

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