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Identification of the machinery involved in the regulation of sugar transporter trafficking by insulin
Reference
ICS00756
Principal Investigator / Supervisor
Professor Stephen Baldwin
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
118,810
Status
Completed
Type
Research Grant
Start date
27/06/1994
End date
27/06/1997
Duration
36 months
Abstract
The aim of the proposed project is to identify components of the protein machinery responsible for the targeting of glucose transporters to specific intracellular locations in 3T3-L1 adipocyte, and for the translocation of these transport proteins to the cell surface in response to the hormone insulin. To this end, intracellular glucose-transporter containing vesicles will be isolated, and their protein components characterised by a combination of microsequencing and CDNA cloning. The roles of individual components in targeting and translocation will then be investigated by using immunological and antisense oligonucleotide strategies, in combination with confocal laser scanning microscopy.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Intracellular Signalling (ICS) [1986]
Funding Scheme
X – not Funded via a specific Funding Scheme
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