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Cell signalling in IL6-induced apoptosis of human myeloid cells
Reference
ICS00611
Principal Investigator / Supervisor
Professor Janet Lord
Co-Investigators /
Co-Supervisors
Dr David Burnett
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
113,709
Status
Completed
Type
Research Grant
Start date
01/01/1994
End date
01/05/1997
Duration
40 months
Abstract
Identification of the events resulting from the binding of a ligand to its receptor and leading to differential gene expression, is a major problem in cell biology today; moreover, understanding the relation between signals for cell survival and programmed cell death will provide insight into the origin of many pathological processes. We aim to determine cell signalling events elicited by IL6 and leading to apoptosis or differentiation in promyeloid cells (U937), specifically to a) define the role of PKC isoforms in apoptosis, b) to investigate cross-talk between IL6 and PKC isoform pathways, particularly PKC-B1 which appears to be a key regulator, and c) investigate signalling events in the nucleus. The use of phorbol esters more selective then TPA in their activation of PKCs is a central feature of these studies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Intracellular Signalling (ICS) [1986]
Funding Scheme
X – not Funded via a specific Funding Scheme
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