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NF-kappaB: novel targets for anti-inflammatory drugs
Reference
ICR07601
Principal Investigator / Supervisor
Professor Ronald Hay
Co-Investigators /
Co-Supervisors
Institution
University of St Andrews
Department
Biology
Funding type
Research
Value (£)
152,190
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/2000
Duration
36 months
Abstract
NF-kappaB transcription factors and IkappaB inhibitor proteins play a central role in the rapid induction of genes transcribed in response to a variety of extracellular stimuli. Signal induction results in phosphorylation and ubiquitination of IkappaBalpha prior to proteasomal degradation and release of NF-kappaB. The objective of this work is to define the mechanism of signal-induced ubiquitination of IkappaBalpha. An in vitro system, using a phospho-mimic of IkappaBalpha as substrate, will be used to identify components of the E1-E2-E3 thioester cascade responsible for IkappaBalpha ubiquitination and determine if the activity of these enzymes is modified after induction. Enzymes displaying specificity for IkappaBalpha will be attractive targets for the design of anti-inflammatory drugs.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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