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The integration of tyrosine kinase and G-protein mediated signalling through the p70 S6 kinase cassette

Reference	ICR07563
Principal Investigator / Supervisor	Professor Graeme Milligan
Co-Investigators / Co-Supervisors	Dr Neil Anderson
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	144,030
Status	Completed
Type	Research Grant
Start date	20/10/1997
End date	20/10/2000
Duration	36 months

Abstract

We have recently provided the first demonstrations that molecularly defined, heterologously expressed, Gi-protein-coupled receptors (GPCRs) can increase the phosphorylation state and cause activation of p70 S6 kinase. Agonists at these receptors are mitogenic and this is prevented by treatment of cells with a selective inhibitor of the p70 S6 kinase signalling cassette. We will now (1) establish the organisation and hierarchy of the protein components of this signalling cassette, (2) compare the regulation of this cassette by GPCRs and receptor tyrosine kinases, (3) define the contributions and points of bifurcation between GPCR-mediated activation of the p70 S6 kinase and ERK MAP kinase signalling cassettes, (4) examine how GPCR activation of the p70 S6 kinase cascade can regulate translational efficiency, and (5) determine the contribution of GPCR activation of the p70 S6 kinase signalling cassette to mitogenesis and regulation of the cell cycle.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integration of Cellular Responses (ICR) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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