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Definition of the regulatory domains of a PtdIns4P 5-kinase Pipkin C and the role of PtdIns(45)P2 as a potential second messenger
Reference
ICR07552
Principal Investigator / Supervisor
Professor Robin Irvine
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
138,743
Status
Completed
Type
Research Grant
Start date
03/11/1997
End date
30/06/2001
Duration
42 months
Abstract
We have purified, sequenced and cloned a novel PtdIns4P 5-kinase, Pipkin C, which is regulated by multiple signalling pathways. The enzyme which contains two putative SH3 domain binding motifs is regulated by dephosphorylation/phosphorylation, by interaction with at least two small molecular weight G-proteins (SMGs), namely Rac and Rho, and by integrin-mediated signals. We aim to identify the domains involved with these different modes of regulation and to use this information to develop tools to compromise them and so define the in vivo role of PtdIns(4,5)P2 in cellular regulation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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