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The integration of tyrosine kinase and phosphatase-regulated pathways which mediate the apoptosis of immature thymocytes
Reference
ICR07546
Principal Investigator / Supervisor
Dr Denis Alexander
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
187,029
Status
Completed
Type
Research Grant
Start date
03/02/1997
End date
15/05/2001
Duration
51 months
Abstract
The aim of this project is to elucidate the integration of T-cell antigen receptor- stimulated signalling cassettes which mediate thymocyte apoptosis. The project will be carried out using the novel technique of retroviral transfection of murine foetal thymic organ culture and will benefit from the experimental advantages provided by the dysfunctional apoptosis of the CD45-null thymus. Phase 1 will focus on the early events of TCR signal transduction coupling, in particular on Lck and Fyn. Phase 2 will investigate the Ras/phosphotyrosine phosphatase 1D and HS1 signalling cassettes and Phase 3 the integration of these signals with Bcl-2 family members. The project will show how the selection of highly specific signalling pathways regulates T-cell death and survival during thymic differentiation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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