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Integration of cAMP-mediated IL-4 receptor signalling in human B lymphocytes

Reference	ICR07544
Principal Investigator / Supervisor	Professor William Cushley
Co-Investigators / Co-Supervisors	Dr Bradford Ozanne
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	148,844
Status	Completed
Type	Research Grant
Start date	01/10/1997
End date	01/05/2001
Duration	43 months

Abstract

This project will study IL-4 driven cAMP/protein kinase A signalling in regulation of gene expression in human B lymphocytes. Preliminary work has demonstrated that IL-4-driven cAMP accumulation causes a loss of activity of protein(s) binding to a negative regulatory element (NRE) in the promoter of the IL-2 receptor alpha chain (CD25) gene. We will now characterise the NRE-binding protein (NRE-BP), define the mechanism by which it is regulated by the cAMP/PKA pathway and, in the later stages of the project, by other pathways. We will also explore the biochemical mechanism by which the IL-4 receptor is linked to cAMP generation, and will address the hypothesis that JAK family tyrosine kinases play a central role in this process.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integration of Cellular Responses (ICR) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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