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Structural studies on activatory and inhibitory molecules of the cyclin-dependent kinases

Reference	ICR07520
Principal Investigator / Supervisor	Professor Jane Endicott
Co-Investigators / Co-Supervisors	Professor Dame Louise Johnson, Professor Martin Noble
Institution	University of Oxford
Department	Laboratory of Molecular Biophysics
Funding type	Research
Value (£)	157,712
Status	Completed
Type	Research Grant
Start date	01/04/1997
End date	31/12/2000
Duration	45 months

Abstract

Sequential activation of the cyclin-dependent protein kinases directs progress through the eukaryotic cell cycle. Loss of CDK regulation has been genetically linked to the development of human cancers. CDK7/cyclin H is required for CDK/cyclin activation and is also a component of transcription factor TFIIH. This project aims to determine by X-ray crystallography the structures of CDK7 alone and in complex with its regulatory molecules, cyclin H and MAT. Synthetic inhibitors of CDKs have aroused interest as potential therapeutic agents and as tools for studying the cell cycle. In a second component of this project we shall elucidate the mode of action of inhibitors upon CDK2 and upon active CDK2/cyclin A.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Integration of Cellular Responses (ICR) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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