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Regulation of gene expression by the signalling responsive transcriptional coactivators p300 and CBP
Reference
ICR07480
Principal Investigator / Supervisor
Professor Neil Perkins
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
156,514
Status
Completed
Type
Research Grant
Start date
20/10/1997
End date
20/11/2000
Duration
36 months
Abstract
The transcriptional coactivators p300 and CBP integrate multiple signalling pathways with DNA-binding proteins that regulate gene expression in response to cell growth and/or cellular stimulation. In addition, both are targets of viral oncoproteins and are implicated as potential tumour suppressors. In this project, the domains of p300 and CBP that mediate transcriptional regulation in response to a variety of signalling pathways will be mapped. Using phage display, specific peptide inhibitors of p300/CBP regulatory interactions will be isolated, allowing their in vivo functions to be analysed.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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