BBSRC Portfolio Analyser
Award details
Structural analysis of the interaction between inositol 1345-tetrakisphosphate and its putative in vivo receptor GAP1 IP4BP
Reference
ICR07477
Principal Investigator / Supervisor
Professor Peter Cullen
Co-Investigators /
Co-Supervisors
Dr Christopher Dempsey
,
Dr Barry Potter
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
196,020
Status
Completed
Type
Research Grant
Start date
09/06/1997
End date
31/08/2000
Duration
38 months
Abstract
To investigate the mechanism by which inositol 1,3,4,5-tetrakisphosphate (InsP4) binds to its recently identified putative InsP4 receptor; GAP1 IP4BP. Experimentally we propose to study the physical requirements within the InsP4 moiety that are necessary for recognition and activation of the receptor. Furthermore we intend to identify and analyse the three dimensional structure of the InsP4-binding domain that allows isomerically specific, high affinity InsP4 binding.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search