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A new pathway to translational control? The role of cell matrix adhesion receptors in protein kinase C-epsilon synthesis
Reference
ICR07473
Principal Investigator / Supervisor
Dr Martin Rumsby
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
143,553
Status
Completed
Type
Research Grant
Start date
01/10/1997
End date
01/10/2000
Duration
36 months
Abstract
A new signalling pathway linking cell matrix adhesion receptors on fibroblasts to translational control of the synthesis of a novel `early response' protein kinase C- epsilon will be characterised. The cell matrix adhesion receptors involved will be defined, activation of MAPKK, MAPK and MAPKAP-kinase 1 (RSK) in the signalling pathway examined and phosphorylation of the translation intermediates BP- 1, eIF-4E and p70S6K following adhesion receptor activation investigated. A need for tyrosine kinases and the actin cytoskeleton in signal pathways from adhesion receptors to PKC-epsilon synthesis will be defined and the role of protein kinase C subspecies alpha, delta or zeta in phosphorylating eIF-4E in the translational control of PKC-epsilon synthesis elucidated.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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