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Regulation of bacterial gene expression by nitrite and nitrate and integration of regulatory signals
Reference
ICR07444
Principal Investigator / Supervisor
Professor Steve Busby
Co-Investigators /
Co-Supervisors
Professor Jeffrey Cole
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
140,089
Status
Completed
Type
Research Grant
Start date
01/09/1997
End date
01/09/2000
Duration
36 months
Abstract
The expression of bacterial operons encoding nitrite reductase is controlled at the level of transcription initiation by four factors: oxygen, nitrite ions, nitrate ions and glucose. We propose to use a combination of biochemical and genetic approaches to discover how signals from these different metabolites are integrated at the promoters of the Escherichia coli nir genes, encoding NADH-dependent nitrite reductase, and the E. coli nrf genes, encoding formate-dependent nitrite reductase. This will provide an important paradigm for understanding the mechanism by which diverse signals interact at promoters to regulate cellular responses to environmental changes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Integration of Cellular Responses (ICR) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
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