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Nuclear re-programming and cellular quiescence
Reference
GTH12613
Principal Investigator / Supervisor
Professor Julian Blow
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
338,052
Status
Completed
Type
Research Grant
Start date
17/07/2000
End date
02/10/2003
Duration
39 months
Abstract
Nuclear transfer studies suggest that overcoming heritable gene repression is important for the success of reprogramming somatic cell nuclei for full embryonic development. Although the biological basis is unknown, recent studies suggest an important role of subnuclear localisation in both heritable gene repression and the timing of DNA replication. We will investigate this using a lymphocyte system where centromeric localisation of heritably repressed genes can be induced. The effect of this change on DNA replicative capacity and gene expression will be assessed following transfer of nuclei to frog egg extracts and by cell fusion to mouse oocytes. This will allow us to test the importance of nuclear organisation for cellular reprogramming.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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