BBSRC Portfolio Analyser
Award details
Targeted modification of the beta-casein locus using a biphasic recombination strategy
Reference
GTH12599
Principal Investigator / Supervisor
Dr James McWhir
Co-Investigators /
Co-Supervisors
Dr Andreas Kolb
Institution
The Roslin Institute
Department
Gene Expression and Development
Funding type
Research
Value (£)
152,292
Status
Completed
Type
Research Grant
Start date
06/03/2000
End date
05/07/2003
Duration
40 months
Abstract
Transgenic animals have become invaluable over the last two decades both as a tool to investigate gene function and regulation and as a source of pharmaceutically relevant proteins. The limited predictability of transgene expression, however, is a major obstacle to realising the full potential of transgenic technology. We propose to assess the ability of a novel biphasic recombination strategy to generate predictable and abundant levels of transgene expression. The results obtained will not only be significant for the future transgene design but also for our understanding of gene regulation at the level of chromatin structure.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search