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Re-targeting adenoviruses to the vascular endothelium for safe and effective gene therapy of diverse pathologies

Reference	GTH12582
Principal Investigator / Supervisor	Professor Andrew Baker
Co-Investigators / Co-Supervisors	Professor Dame Anna Dominiczak, Professor Robert Hawkins, Professor Gordon Jayson, Dr Sarah Watkins
Institution	University of Glasgow
Department	Inst of Cardiovascular &Medical Sci
Funding type	Research
Value (£)	331,314
Status	Completed
Type	Research Grant
Start date	17/01/2000
End date	31/10/2003
Duration	45 months

Abstract

The development of an efficient gene targeting system for the vascular endothelium is a pre- requisite for gene therapy to be fully exploited in diverse clinical situations. We have previously developed an endothelial cell-specific gene delivery system by incorporating novel targeting peptides and cell-specific promoters into adenoviral vectors. We wish to optimise gene delivery in vitro and in vivo and compare this for efficacy and persistence of gene expression to non-targeted adenoviral vectors. Using model therapies, the effect of overexpression of vasodilator genes from the endothelium in hypersensitive rats and the effect of overexpression of cytotoxin genes in the angiogenic endothelium of cancer will be evaluated.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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