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Mesenchymal stem cells in wound healing

Reference	GTH12567
Principal Investigator / Supervisor	Professor M Ferguson
Co-Investigators / Co-Supervisors	Dr Sharon O'Kane
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	246,437
Status	Completed
Type	Research Grant
Start date	03/04/2000
End date	03/04/2003
Duration	36 months

Abstract

Wound healing involves the use of re-structuring and cellular re-population of tissue that has undergone trauma. The hypothesis that circulating stem/primitive cells are incorporated into healing wounds will be investigated using a variety of in vitro and in vivo experimental approaches, including cell lineage labelling, and bone marrow transplantation between Lac Z positive transgenic mice and their syngeneic hosts. Experimental investigations using specific cytokines will be determine the signals for release of circulating stem cells and for their incorporation into the healing wounds. The hypothesis that these incorporated circulating stem cells rejuvenate the dermal stem cell population will be investigated using double and triple labelling for markers of cellular senescence as well as exogenous experimental applications of culture expanded stem/primitive cell populations.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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