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Investigation into relationships between haematopoietic and liver stem cells and their differentiation potential
Reference
GTH12558
Principal Investigator / Supervisor
Professor Alastair Strain
Co-Investigators /
Co-Supervisors
Dr Heather Crosby
,
Professor Stefan Hubscher
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
157,504
Status
Completed
Type
Research Grant
Start date
01/09/2000
End date
01/09/2003
Duration
36 months
Abstract
We have recently identified cells in human liver with features of bi-potential stem cells; that is the capacity to grow then differentiate into hepatocytes or biliary epithelium. In this proposal, we shall test the hypothesis that cells with hepatic lineage potential are present in haematopoietic tissue. Cells from human bone marrow, fetal liver and cord blood will be fractionated and characterised. The extra-cellular matrix components and soluble growth factors/cytokines which regulate clonal expansion and differentiation of these cells in vitro will be determined. The aim is to establish a source of clonal liver cells which can ultimately be used to generate large numbers of human liver epithelial cells for clinical studies.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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