Award details

Peptide-targeted non-viral vectors for gene therapy

Reference	GTH12550
Principal Investigator / Supervisor	Professor Stephen Hart
Co-Investigators / Co-Supervisors	Professor Alethea Tabor
Institution	University College London
Department	Institute of Child Health
Funding type	Research
Value (£)	161,540
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

A random library of cyclic peptides will be displayed in the major coat protein subunit, pVIII, of the filamentous phage fd. This library will be used to pan for novel targeting ligands in multiple organs, tissues and cells. High-affinity phage will be assessed for their capacity for cell entry and thus the suitability of the displayed peptide for targeted vector development. Peptides will be synthesised and incorporated into a high efficiency lipopolypex vector system and evaluated in transfection experiments. Peptide design features will also be optimised in transfections. This project will lead to the development of enhanced non-viral vector systems with high tissue and cell-type specificity and great potential for gene therapy.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme	X – not Funded via a specific Funding Scheme

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