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The positional specification of neural stem cells
Reference
GTH12546
Principal Investigator / Supervisor
Professor Jack Price
Co-Investigators /
Co-Supervisors
Professor Helen Hodges
Institution
King's College London
Department
Institute of Psychiatry
Funding type
Research
Value (£)
194,250
Status
Completed
Type
Research Grant
Start date
14/02/2000
End date
14/02/2003
Duration
36 months
Abstract
We shall investigate the role that the positional specification of neural stem cells plays in directing brain repair. Preliminary data indicate that immortalised neural stem cell lines carry a positional specification, as determined by the combination of homeobox transcription factors that they express. Moreover, different lines carry a different specification. We will use in vivo and in vitro systems to ask what neurogenic genes are activated by these different cell lines during neurogenesis, what neuronal types are generated, and the role that tissue environment plays in these outcomes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Gene Technologies Underpinning Healthcare (GTH) [1999]
Funding Scheme
X – not Funded via a specific Funding Scheme
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