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Horizontal gene flow between bacteria in soil and gene flow within the streptomycetes
Reference
GM114200
Principal Investigator / Supervisor
Professor Elizabeth Wellington
Co-Investigators /
Co-Supervisors
Professor Nigel Burroughs
,
Dr Sharon Egan
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
284,576
Status
Completed
Type
Research Grant
Start date
02/04/2001
End date
01/09/2004
Duration
41 months
Abstract
Horizontal gene transfer between bacteria in soil will be investigated using the streptomycin biosynthesis and resistance gene cluster of S. griseus as a model system to determine origin, frequency, and relative timescale of transfer. The dissemination of clustered genes will be studied using strA, the resistance gene for initial screening of community DNA and bacterial isolates. Four distinct field sites with differing land- use will be sampled, one site has a strong selection pressure via use of streptomycin as a crop bacteriocide. HGTs will be established using phylogenetic incongruency, GC content, and codon usage analysis. Within actinomycete populations the role of HGT in the evolution of antibiotic production will be investigated.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Gene Flow in Plants and Microorganisms (GM1) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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