Award details

The stability of transgene expression in plants; the impact of virus infection

Reference	GM114175
Principal Investigator / Supervisor	Dr Sue Angell
Co-Investigators / Co-Supervisors	Professor George Lomonossoff
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	198,172
Status	Completed
Type	Research Grant
Start date	01/09/2001
End date	01/09/2004
Duration	36 months

Abstract

We will investigate the effects of virus infection on the expression of transgenes in plants exhibiting different manifestations of gene silencing. Many plant viruses encode suppressors of transgene silencing. Thus, virus infection of genetically modified (GM) crops may change the expression of transgenes through virus-mediated suppression of transgene silencing, with implications for the properties of the GM crops. Initially, we will use model plants and a range of different transgenic lines (e.g. different transgene copy number, promoters, etc). This will allow us to identify which types of transgenic lines are most influenced by virus infection and will suggest ways of overcoming the virus-induced fluctuations in transgene expression.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Flow in Plants and Microorganisms (GM1) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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