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Do transgenes predictably alter the expression of the genome? Using wheat grain-filling as a model

Reference	GM114152
Principal Investigator / Supervisor	Professor Peter Shewry
Co-Investigators / Co-Supervisors	Professor Keith Edwards, Professor Malcolm Hawkesford, Professor Michael Holdsworth
Institution	Rothamsted Research
Department	Plant Biology & Crop Science
Funding type	Research
Value (£)	347,144
Status	Completed
Type	Research Grant
Start date	03/12/2001
End date	02/05/2005
Duration	41 months

Abstract

We intend to determine if (and how) introduced transgenes alter the expression of the wheat genome. We will develop methodology and generate data to be used to assess the predictability of trait alterations arising from transgenesis. To do this we will use wheat lines containing biologically active and inactive transgenes expressed during seed development, to study the transcriptome and total protein profile. In addition we will compare genome expression in conventionally bred wheat varieties with wheat containing transgenes designed to achieve the same trait effect. These experimental approaches will allow us to determine whether transgenes alter genome expression predictably.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Gene Flow in Plants and Microorganisms (GM1) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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