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Physical and gene mapping within a quantitative trait locus (QTL)
Reference
GAT09150
Principal Investigator / Supervisor
Professor Alan Archibald
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Genetics and Genomics
Funding type
Research
Value (£)
96,363
Status
Completed
Type
Research Grant
Start date
03/08/1998
End date
03/08/2000
Duration
24 months
Abstract
The aims of this project are to construct physical and gene maps of a QTL as a prelude to identifying trait genes within the QTL. Briefly, a physical map spanning the QTL will be established by radiation hybrid mapping with anonymous DNA markers (microsatellites). Genes will be added to this radiation hybrid map and the resulting map compared to the gene maps of human and mice. Large genomic fragments from the QTL will be isolated (in BAC and YAC clones) as a source of further genetic markers for parallel genetics studies and used to identify further genes that map to the QTL. The gene map of the QTL will be regularly compared to those of human and mouse. Genes that map to the QTL or the homologous regions in humans and mice will be considered as candidates for the trait gene. The credentials of strong candidate genes will be tested. A QTL influencing fat which has been mapped to pig chromosome 4 will be the subject of this study.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genome Analysis of Agriculturally Important Traits (GAT) [1997-1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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