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Conservation of gene order between avian and mammalian genomes: a detailed comparison based on genes that map to human chromosome 19
Reference
GAT09125
Principal Investigator / Supervisor
Professor David Burt
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Genetics and Genomics
Funding type
Research
Value (£)
155,568
Status
Completed
Type
Research Grant
Start date
01/07/1998
End date
01/07/2001
Duration
36 months
Abstract
Comparison of the genetic maps of chicken and man predict 74 conserved segments (does not consider gene order) almost twice as conserved as the mouse with 150 conserved segments. However, the mapping data in the chicken is still too sparse to conclude that gene order is also conserved. There are two problems (i) the number of genes mapped in the chicken is low (121 homologues, May `97) and (ii) most of the human data is reported as cytogenetic locations of low resolution, so even when we have three or more genes mapped in the chicken, we still cannot determine the gene order in man. The aim of this project is to focus on a single human chromosome, HSA19 for which a physical map is well developed (at the Lawrence Livermore National Laboratory, USA), mostly based on overlapping cosmid clones, with more than 400 genes already mapped and ordered. Comparison of the maps of mouse and man, identified approximately 20 conserved segments on this chromosome. The plan is to map these segments in the chicken and compare the maps of chicken, mouse and man, to assess the degree of conservation of gene order and to identify the boundaries between conserved regions.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genome Analysis of Agriculturally Important Traits (GAT) [1997-1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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