Award details

Construction and characterisation of a resource population of pigs to map genes which influence resistance to salmonellosis

Reference	GAT09105
Principal Investigator / Supervisor	Dr Timothy Wallis
Co-Investigators / Co-Supervisors	Dr N Bumstead
Institution	The Pirbright Institute
Department	Div of Microbiology Compton
Funding type	Research
Value (£)	83,356
Status	Completed
Type	Research Grant
Start date	01/08/1998
End date	01/08/2000
Duration	24 months

Abstract

A resource family of pigs derived from pig lines resistant and susceptible to salmonellosis will be screened for susceptibility to salmonellosis following oral inoculation with Salmonella choleraesuis. DNA samples from the individuals will be sampled for subsequent qualitative trait locus analysis. Individuals will be screened for polymorphisms in nramp1, LPS and sal1, genetic loci known to influence the susceptibility of other animal species to salmonellosis. Polymorphisms will be correlated to the bactericidal activity and cytokine responsiveness of macrophages, and susceptibility of macrophages of donor animals to infection.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genome Analysis of Agriculturally Important Traits (GAT) [1997-1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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