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Functional genomics and digestive physiology of Globodera: underpinning new targets for control via C. elegans genomics

Reference	GAN13136
Principal Investigator / Supervisor	Prof. Howard Atkinson
Co-Investigators / Co-Supervisors	Professor David Coates, Dr Catherine Lilley, Professor Peter Urwin
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	188,864
Status	Completed
Type	Research Grant
Start date	01/12/2000
End date	01/12/2003
Duration	36 months

Abstract

The work will focus on digestive physiology and utilise C. elegans genomics. Library screens will isolated genes that encode digestive enzymes of Globodera. RNAi will identify those enzymes essential to food digestion by C. elegans and Globodera. RNAi 'knock-outs' plus diet manipulation will identify orthologous genes for enzymes required for digestion of either protein or carbohydrate. Transformation of C. elegans with non-orthologous genes from Globodera will 'rescue' function in C. elegans on diets normally unsuitable for it. The two key aims are: 1) to identify key digestive enzymes of Globodera as novel targets for further design of novel resistant crops and 2) to found a UK plant nematode genomics partnership with industry.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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