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Identification and functional analysis of synaptic transmission dependent genes in Drosophila
Reference
GAN13123
Principal Investigator / Supervisor
Professor Michael Bate
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Zoology
Funding type
Research
Value (£)
285,824
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
01/08/2003
Duration
39 months
Abstract
Synaptic transmission is required for functional maturation of the CNS and to induce gene transcription involved in neuronal plasticity. Our aim is to use Drosophila to identify genes that are transcriptionally regulated by synaptic transmission during development. Differential screening and cDNA microarrays will be used to compare gene expression in normal embryos and embryos with no synaptic transmission. RNA interference knockouts of confirmed positive clones will be assessed initially with a rapid behavioural and anatomical screen. Detailed electrophysiological and structural investigation will identify those clones corresponding to genes required for the functional maturation of the CNS. These genes will be mapped and sequenced.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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