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Functional analysis of an emerging family of zinc-metallopeptidase genes in the Drosophila genome

Reference	GAN13115
Principal Investigator / Supervisor	Professor Elwyn Isaac
Co-Investigators / Co-Supervisors	Professor David Coates, Dr Alan Shirras, Professor Anthony Turner
Institution	University of Leeds
Department	Inst of Integrative & Comparative Biolog
Funding type	Research
Value (£)	163,204
Status	Completed
Type	Research Grant
Start date	06/11/2000
End date	29/05/2004
Duration	43 months

Abstract

Members of the neprilysin (NEP)/endothelin-converting enzyme (ECE) family of zinc-metallopeptidases are responsible for the limited hydrolysis of pro- proteins/peptides that are key regulators of cellular and physiological processes (e.g. embryogenesis, bone metabolism, cardiovascular control, immunity and pain). Genome sequencing projects show that NEP/ECEs are part of a larger gene family and it is likely that new family members may also have important roles regulating physiology/behaviour in animals. We propose to discover new physiological roles for the NEP/ECE family by studying all members (currently 7) of this evolutionary conserved family of genes in Drosophila melanogaster, an organism that is amenable to a global analysis of gene function. For all family members, we will determine expression patterns, study the gene-specific loss-of- function, the consequence of ectopic expression and characterise the substrate specificity of recombinant proteins.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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