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The role of NMDA-receptor and intracellular calcium signalling genes in mouse olfactory learning

Reference	GAN13112
Principal Investigator / Supervisor	Professor Keith Kendrick
Co-Investigators / Co-Supervisors	Professor Eric Keverne, Dr Lawrence Wilkinson
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	312,188
Status	Completed
Type	Research Grant
Start date	01/06/2000
End date	31/12/2003
Duration	43 months

Abstract

This project will investigate olfactory learning in five transgenic mouse lines with genetic disruptions to the NMDA/Ca2+ signalling cascade. Using a number of social and non-social olfactory learning paradigms where memory formation can be both extremely fast and of varying duration it will delineate: 1) the different genetic requirements for long and short term memory; 2) the recruitment of different brain areas beyond those specifically processing olfactory information but which depend upon genomic changes occurring within them; and 3) those genomic changes in tertiary olfactory projection regions which may have involvement in aspects of olfactory learning but are not unique to it. Teasing apart these multiple levels at which a given gene may influence behaviour will require a combination of a number of different olfactory learning tasks, together with molecular neuroanatomical, electrophysiological and in vivo neurochemical techniques.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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