Award details

Interactions amongst imprinted genes in endocrine signalling

Reference	GAN13111
Principal Investigator / Supervisor	Dr Gavin Kelsey
Co-Investigators / Co-Supervisors	Dr Wendy Dean, Professor William Fraser
Institution	Babraham Institute
Department	Developmental Genetics and Imprinting
Funding type	Research
Value (£)	218,604
Status	Completed
Type	Research Grant
Start date	01/10/2000
End date	01/10/2003
Duration	36 months

Abstract

Genomic imprinting is a mechanism of gene control by which one parental allele is silenced. Imprinting participates in multiple physiological processes in mammals. An emerging theme is that paternally expressed and maternally expressed genes interact antagonistically in common pathways. In a screen for imprinted genes, we identified two oppositely imprinted transcripts at the Gnas locus. Gnas encodes the G-protein subunit, Gs alpha, which mediates signalling by G-protein coupled receptors. The new transcripts are the paternally expressed Gnasxl, encoding an extra-large isoform of Gs alpha, and maternally expressed Nesp, encoding a protein of neuroendocrine cells. We shall test the hypothesis that Gnasxl and Nesp interact in a pathway mediated by Gs alpha. Knock-outs of Gnasxl and Nesp will be made, and effects on endocrine pathways, in particular PTH action, assessed.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search