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Molecular basis of cerebellar motor memory

Reference	GAN13106
Principal Investigator / Supervisor	Professor Christopher Yeo
Co-Investigators / Co-Supervisors	Professor Karl Giese, Professor Stephen Hunt
Institution	University College London
Department	Cell and Developmental Biology
Funding type	Research
Value (£)	380,200
Status	Completed
Type	Research Grant
Start date	01/06/2000
End date	15/08/2003
Duration	38 months

Abstract

We propose to identify proteins involved in the formation of memories. Eyeblink conditioning is a simple form of motor learning and recent studies have identified a small region of the cerebellum critical for its acquisition and consolidation. This precise anatomical specificity will allow us to identify memory-related molecules using a PCR differential display strategy. Their mouse homologues will be cloned and their expression patterns in a range of mouse motor learning tasks will be examined. In order to determine the role of the major memory-related molecules, gene targeting studies will be needed. As a first step, we will clone constructs for future gene inactivation studies.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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