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Functional analysis of imprinted genes involved in placental development
Reference
GAN13105
Principal Investigator / Supervisor
Professor Wolf Reik
Co-Investigators /
Co-Supervisors
Professor Colin Sibley
Institution
Babraham Institute
Department
Developmental Genetics and Imprinting
Funding type
Research
Value (£)
149,200
Status
Completed
Type
Research Grant
Start date
01/05/2000
End date
30/04/2003
Duration
36 months
Abstract
The aim is to combine physiology and molecular genetics in an integrative approach to determine the function of parentally imprinted genes involved in placental development. Numerous studies in mice have demonstrated the importance of imprinted genes in placental development, but virtually nothing is known about their function. The placental phenotypes of 7 existing knockout mouse strains will be analysed and functional assays performed to relate the developmental defects to placental nutrient transfer. Additional knockout mice will then be analysed as they become available, including combinations of knockouts, so that interactions between the genes can be investigated. As well as establishing the role of imprinted genes in placental development, this study will provide much needed basic information on structure-function relationships in the placenta.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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