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Defining the molecular phenotype of dopaminergic precursor cells: identification of candidates for cell manipulation in vitro
Reference
GAN13103
Principal Investigator / Supervisor
Dr Nicholas Allen
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Cognitive and Behavioural Neuroscience
Funding type
Research
Value (£)
190,436
Status
Completed
Type
Research Grant
Start date
26/02/2001
End date
25/02/2004
Duration
36 months
Abstract
Midbrain dopaminergic neurones are of critical physiological and medical importance. A detailed understanding of their developmental cell lineage and the molecular mechanisms that specify the cell fate and differentiation of dopaminergic precursor cells is fundamental to strategies that aim to develop cells expressing defined neurotransmitters for clinical transplantation. This proposal will identify the genes that are specifically expressed in dopaminergic precursor cells in the mouse, and define gene expression profiles for these cells. This will be achieved using a unique mouse model expressing a reporter gene in the precursor cells, coupled to flow cytometry and state-of-the-art gene expression analysis and gene cloning. Expression of identified genes will be analysed in vivo, and genes will be evaluated as candidates to manipulate the cell fate of neural precursor cells in vitro.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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