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Development of inducible conditional knockout mice to analyse gene function in melanocyte/keratinocyte physiology
Reference
GAN13094
Principal Investigator / Supervisor
Dr David Greenhalgh
Co-Investigators /
Co-Supervisors
Dr Malcolm Briden Hodgins
Institution
University of Glasgow
Department
Institute of Cancer Studies
Funding type
Research
Value (£)
274,444
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
01/07/2004
Duration
44 months
Abstract
The function of melanocytes to produce and deliver melanin to keratinocytes depends on intimate cell-cell interactions within the epidermal melanin unit. Recent studies show that keratinocyte derived factors dominate the melanocyte environment. However, in vivo, the precise nature of these interactions remain unknown. A transgenic model of cutaneous melanocyte-specific knockout mice will be developed to address this problem by exploiting tyrosinase targeting specificity coupled to an inducible cre/loxP recombinase gene switch. This study aims to identify cell-cell factors critical for normal melanocyte physiology via deregulation of growth factor responses (c-kit, FGFR-1) and keratinocyte adhesion interactions (E-cadherin).
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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