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Using genomics and genetics to elucidate function of the multigene V-ATPase family
Reference
GAN13093
Principal Investigator / Supervisor
Professor Julian Dow
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Molecular Genetics
Funding type
Research
Value (£)
310,260
Status
Completed
Type
Research Grant
Start date
17/07/2000
End date
17/07/2003
Duration
36 months
Abstract
Integrative physiology and functional genomics are united by the desire to move from gene to function. If both physiological and genetic approaches can be combined in a single organism, powerful leverage of genomic information into functional insight can be made. This synergy will be exploited in the analysis of the V-ATPase gene family in Drosophila melanogaster. V-ATPases present a unique target for such study, because they are composed of multiple subunits, some encoded by single genes, and some by multiple transcripts. They also play multiple roles in the endo- and plasma membrane systems. We know that these genes are expressed in highly tissue-specific fashion, and we have detailed both a wild-type and mutant phenotype that appears conserved among subunits. So a combination of genetics, sequence analysis, promoter analysis, transgenics and physiological analysis will produce insights into function not possible in any other organism.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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