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Comparative integrative physiology of Diptera: applying Drosophila genetics to vector biology

Reference	GAN13091
Principal Investigator / Supervisor	Professor Julian Dow
Co-Investigators / Co-Supervisors	Professor Shireen Davies, Professor Ian Maudlin
Institution	University of Glasgow
Department	Molecular Genetics
Funding type	Research
Value (£)	257,774
Status	Completed
Type	Research Grant
Start date	26/11/2000
End date	01/05/2004
Duration	41 months

Abstract

Integrative physiology and functional genomics are united by the desire to move from gene to function. This implies gene targeting and reverse genetics, which in turn require genetic model organisms. However, genetic models are frequently not objects of economic importance. Recognising that many insect pests are Dipteran, we propose a methodology for exploiting our understanding of Drosophila signalling and transport to study similar processes in tsetse flies and sandflies, between them responsible for 20 M trypanosomatid diseases in humans alone. The project will apply genetic, physiological, pharmacological, histochemical and molecular techniques to provide a unique insight into excretory function in the Malpighian tubules of the three species, and in doing so will validate the principle of linking economically important organisms with their phylogenetically closest genetic model.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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