Award details

Microarray-mediated analysis of gene expression in the T lymphocyte lineage of the diabetes prone BB rat

Reference	GAN13085
Principal Investigator / Supervisor	Dr Geoff Butcher
Co-Investigators / Co-Supervisors	Dr James Ross Miller
Institution	Babraham Institute
Department	Babraham Institute Department
Funding type	Research
Value (£)	173,312
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	30/06/2004
Duration	46 months

Abstract

The BB rat is known to develop autoimmune insulin dependent diabetes mellitus (IDDM) at a high frequency. Two genes play a key role in this disease model: the RT1u haplotype of MHC class II and the autosomal recessive mutation lymphopenia (lyp). Lyp has been mapped within rat chromosome 4, but remains as yet uncloned. Recent work in our laboratory has indicated that lyp causes an increased level of apoptosis of mature thymocytes and hence prevents the development of a normal T cell pool with appropriate regulatory subsets. This project will use microarray technology firstly to categorise gene expression in mature thymocytes and/or naareve peripheral T cells and secondly to look for differential levels of gene expression between rats with and without the lyp mutation.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search