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Genes controlling photoinduced gonadotrophin releasing hormone release
Reference
GAN13079
Principal Investigator / Supervisor
Professor Peter Sharp
Co-Investigators /
Co-Supervisors
Dr Timothy Boswell
Institution
The Roslin Institute
Department
Roslin Biocentre
Funding type
Research
Value (£)
260,636
Status
Completed
Type
Research Grant
Start date
01/08/2000
End date
30/04/2004
Duration
45 months
Abstract
Identification of the cascade of gene expression in neural pathways transducing photoinduced changes in gonadotrophin releasing hormone (GnRH) release is an intractable problem using traditional technologies. This project will address this problem by: 1) using a chicken first day release model of photoinduced GnRH release in which the underlying sequence of changes in gene expression can be precisely timed; 2) identifying sequential changes in photoinduced gene expression in the hypothalamus using a microarray of cDNAs prepared using information on existing chicken ESTs in GenBank and from an 'in house' EST hypothalamic library; and 3) using antisense to genes identified in 2) to prove their function in photoinduced GnRH release.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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